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필로카핀.투여 방법에 따른 구강 건조증 환자의 치료 효과에 관한 연구
COMPARATIVE STUDY ON THE EFFECTIVENESS OF pII,OCARPINE IN XEROSTOMIA ACCORDING TO THE METHOD OF ADI\INISTRATION

대한구강내과학회지 1994년 19권 2호 p.25 ~ 46

이선경, 현기용, 이승우,

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이선경 (  ) - 서울대학교 치과대학 구강진단·구강내과학
현기용 (  ) - 서울대학교 치과대학 구강진단·구강내과학
이승우 (  ) - 서울대학교 치과대학 구강진단·구강내과학

KMID : 0355219940190020025

Abstract

The purposes of this study were to investigate the effect of pilocarpine-containing chewing gum for the treatment of xerostomia and to compare the effect of pilocarpine-containing chewing gum with that of pilocarpine oral administration. The 20 -subjective and objective xerostomic~ patients were included in this study and divided into 3 groups. Five subjects were included in gum base chewing group, 10 in pilocarpine-containing gum chewing, and 5 in piocarpine. oral administration. The author measured unstimulated whole salivary flow rate, stimulated parotid salivary flow rate, pH of resting whole saliva, viscosity of stimulated whole saliva, and subjective symptoms and discomforts using VAS(visual analogue scale) at the beginning of the experiment. And the author investigated the changes of these factors at 1, 2, 3, and 4 weeks after.
The obtained results were as follows:

1. There were significant increases in the unstimulated whole salivary flow rate in pilocarpine-containing gum chewing and pilocarpine oral administration groups. But there was no significant difference between pilocarpine-containing gum chewing and pilocarpine oral administration groups.
2 There was a significant increase in the stimulated parotid salivary flow rate in pilocarpine-containing gum chewing group. But there was no significant difference between pilocarpine-containing gum chewing and pilocarpine oral administration groups.
3.The change of salivary pH showed the increasing pattern in all groups. But there was no significant difference among groups.
4. There were no significant changes in the values of salivary viscosity in all groups through the experimental period. 5. There were significant decreases of VVAS(visual analogue scale) in the degree of subjective symptoms and
discomforts in pilocarpine-containing gum chewing and pilocarpine oral administration groups. But there was no significant difference between pilocarpine-containing gum chewing and pilocarpine oral administration groups.